Tesofensine and Phentermine

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Tesofensine and Phentermine DermFx

The combination of tesofensine and phentermine is being explored for use in weight loss due to the appetite-suppressing and metabolism-boosting effects achieved through different mechanisms of action. (1, 2)

Weight loss can be a challenging journey to embark on, especially when diet and exercise alone fail to deliver impactful results. Whether you’re struggling with stubborn fat, constant cravings, or low energy, finding a solution that truly works can feel overwhelming. Fortunately, thanks to advancements in prescription-based wellness, there are now non-surgical options that can help you on your weight loss journey. Among the most effective are tesofensine and phentermine, two powerful medications that work synergistically to suppress appetite, enhance metabolic function, and accelerate fat loss.

DermFx serves the Orange County and Los Angeles areas and specializes in numerous treatments designed to help you achieve a variety of aesthetic and wellness goals. Our expert team of providers at DermFx is proud to offer these innovative weight loss solutions to patients throughout Southern California. We will work closely with you to create a personalized plan, helping you take control of your wellness, your confidence, and your future. If you’ve hit a plateau on your weight loss journey or are simply ready to jumpstart your transformation, tesofensine and phentermine could be the game-changing combination you’ve been waiting for.

To learn more about the tesofensine and phentermine treatments offered at DermFx, schedule a personal consultation by contacting one of our five locations:

About Tesofensine and Phentermine

Tesofensine and phentermine are two prescription medications designed to support weight loss by targeting different but complementary mechanisms in the brain. Tesofensine works by increasing levels of neurotransmitters such as dopamine, norepinephrine, and serotonin, which help curb appetite and boost metabolism. (3) Phentermine, meanwhile, is a well-known appetite suppressant that stimulates the release of brain chemicals that reduce hunger.

This dual-action approach allows for a comprehensive metabolic reset, helping patients break through weight loss plateaus, improve dietary adherence, and experience enhanced energy levels. When combined with lifestyle adjustments, this treatment has the potential to help individuals reduce body fat safely and effectively under medical supervision.

Benefits

There are numerous benefits associated with tesofensine and phentermine treatments, which is why these treatments have become so heavily sought after at DermFx. A few of these benefits include:

  • Weight Loss: The combination of these medications is being explored as an effective way to aid in weight loss.
  • Appetite Suppression: Individuals can feel fuller and more satisfied after eating smaller portions.
  • Metabolism Boost: This treatment can help enhance metabolic rate, leading to increased calorie burning, even at rest.
  • Improved Energy Levels: Users often report enhanced energy after starting their regimen, allowing for increased physical activity.
  • Body Composition Improvement: These medications may help reduce body fat while preserving lean muscle mass.
  • Easier Lifestyle Changes: With a more controlled appetite, individuals often find it easier to adopt healthier dietary habits.
  • Reduced Risk of Obesity-Related Comorbidities: Regular use can help mitigate health risks related to obesity, including diabetes and cardiovascular diseases.
  • Short-term Efficacy: Phentermine is known for its quick results, which are usually noticeable within weeks, making it suitable for motivated weight loss.

With the ample benefits associated with these revolutionary treatments established, if you are interested in exploring how you can experience some of these benefits for yourself, schedule a personal consultation online at one of our five locations. To schedule your consultation over the phone, please call the location most convenient for you:

Ideal Candidates

A major reason why Tesofensine and Phentermine have become highly sought-after treatments at DermFx is that they appeal to a wide range of potential candidates. Ideal candidates for this treatment often include people who:

  • Struggle to lose weight with diet and exercise alone.
  • Experience frequent cravings or emotional eating.
  • Prefer a prescription-based, non-surgical solution.
  • Are in good overall health, but have a BMI that classifies as overweight or obese.
  • Are motivated to adopt healthier lifestyle habits during treatment to enhance and maintain results.

Whether or not you are eligible for tesofensine or phentermine treatments at DermFx will ultimately be determined during your personal consultation.

Personal Consultation

The first step in your weight loss transformation begins with a personal consultation at DermFx. During this consultation, one of our expert providers will review your medical history, perform a physical assessment, and discuss your concerns and objectives. We will explore your past experiences with weight loss, current eating and activity habits, and any potential health conditions that could influence treatment outcomes.

After we gain a clear understanding of your goals and physiology, the DermFx team will design a custom weight loss treatment plan tailored specifically to your needs. This plan may include a combination of prescription medication, nutritional guidance, and lifestyle coaching. As part of your treatment plan, we will also ask you to schedule follow-up appointments so we can monitor your progress on your journey.

To schedule your personal consultation, contact DermFx online or by giving us a call at one of our five locations:

Preparation

Preparing for your prescription weight loss treatment at DermFx is rather simple. You’ll undergo a basic screening process that may include:

  • Blood pressure and heart rate checks
  • Review of medications and any pre-existing conditions
  • Lab work, if deemed necessary
  • Education on possible side effects and safety protocols

You may be asked to avoid stimulants or alcohol during your course of treatment and stay hydrated throughout the process. Our staff will walk you through everything needed to begin confidently and safely. One of the benefits of these treatments is that, unlike many traditional weight loss procedures, these treatments do not require extensive preparation.

Procedure

This is a medical weight loss program, not a procedure in the traditional sense. Once prescribed, you will begin taking your medications, either Tesofensine, Phentermine, or a combination, according to your provider’s instructions. In most cases, these are oral medications taken once daily in the morning. You may be required to check in regularly with our medical team at DermFx, where we will evaluate your progress, adjust dosages as needed, and offer support for any side effects or questions you might have. Most patients find that their medication starts working within the first week, providing a noticeable reduction in appetite and a boost in energy.

Recovery and Results

Unlike many traditional weight loss treatments, there is no recovery period involved with these medications, and the majority of results will typically develop over the course of several weeks. Most patients begin to notice weight loss and a decrease in hunger within the first 7 to 14 days. With consistent adherence to the treatment plan and nutritional guidelines, patients can expect gradual, sustained weight loss over several months.

Some may experience minor side effects such as dry mouth, increased heart rate, or mild insomnia during the adjustment period, but these effects often subside as the body adapts to the new regimen.

Long-term results depend on your commitment to maintaining a healthy lifestyle, but many report significant improvements in body composition, mood, and self-esteem when combining these medications with healthy lifestyle habits.

Corresponding Procedures

Tesofensine and Phentermine DermFx

DermFx specializes in numerous different types of treatments, and many patients choose to undergo additional treatments to achieve comprehensive rejuvenation. While this is completely optional, the DermFx team will be happy to help you explore any of the numerous treatments we offer that you could potentially benefit from.

Because tesofensine and phentermine have been shown to produce significant weight loss results, many patients who seek these treatments might notice excess skin once their results begin to appear. As such, many patients undergoing tesofensine and phentermine might benefit from our facial treatments to tighten skin or address wrinkles. Wrinkles and sagging skin are often caused by a loss of facial volume due to losing a significant amount of weight in a short period of time. DermFx is well-known for its variety of injectable treatments that address this very issue.

To explore the other procedures and treatments we offer, we encourage you to read the DermFx blog!

Cost of Tesofensine and Phentermine Treatment in Orange County and Los Angeles

The total cost of treatment will vary depending on a variety of factors, including your dosage plan, medication type, and follow-up schedule. During your consultation, our team will provide a transparent pricing breakdown and help you explore any of our promotional offers or financing options. We also encourage you to enroll in our DermFx Rewards program for special pricing and exclusive savings.

FAQ

What are tesofensine and phentermine used for?

These medications are used to suppress appetite and accelerate weight loss by increasing neurotransmitter activity in the brain.

Are these treatments safe?

Yes. When prescribed and monitored by a qualified provider, both medications have strong safety profiles and are widely used in medical weight loss.

How quickly will I see results?

Most patients begin seeing noticeable appetite control within the first week and measurable fat loss within the first month.

Do I need to follow a special diet?

We recommend combining the medications with a moderate-calorie diet rich in whole foods for best results.

Can I take these medications long term?

Treatment duration will depend on your goals and response. Some patients cycle on and off under medical guidance to maintain results and prevent tolerance.

References

  1. PubChem. Tesofensine. Nih.gov. Published 2025. Accessed April 24, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/Tesofensine
  2. Lewis KH, Gudzune KA, Ard JD. Phentermine in the Modern Era of Obesity Pharmacotherapy: Does It Still Have a Role in Treatment? Current Obesity Reports. Published online January 3, 2024. doi:https://doi.org/10.1007/s13679-023-00546-9
  3. Perez CI, Luis-Islas J, Lopez A, et al. Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons. PLoS ONE. 2024;19(4):e0300544-e0300544. doi:https://doi.org/10.1371/journal.pone.0300544
  4. Phentermine. PubMed. Published 2012. https://www.ncbi.nlm.nih.gov/books/NBK547916/